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Human Growth Hormone Supplements HMG Injection For Fertility 75iu/vial
What are gonadotrophins?
Gonadotrophins are injectable hormones that can be used to treat fertility problems in women and men. Gonadotrophins help women to ovulate and men to improve their sperm count.
What's the success rate of gonadotrophins?
Up to 85 per cent of women with an ovulation problem will ovulate after using gonadotrophins. About 23 per cent of women with clomifene-resistant PCOS conceive while using gonadotrophins and about 20 per cent have a live birth.
Other factors that can affect conception are:
the time in your cycle you have sex
the speed and ability to move (motility) of your partner's sperm
Gonadotrophins are often used in IVF treatments because controlling the development and release of mature eggs from your ovaries increases your chance of success.
Are gonadotrophins right for me?
You are most likely to be offered these drugs if you:
Have polycystic ovary syndrome and have not ovulated in response to clomifene citrate.
Are having assisted-conception treatments, such as in-vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI).
If your partner has a hormonal imbalance linked to a low sperm count, or poor sperm quality or motility, he may be offered gonadotrophins.
Talk to your doctor about your chances of success using these drugs. If you're paying for your treatment, be clear about how much these drugs will cost. This way you can weigh up the pros and cons as best you can before beginning treatment.
How do gonadotrophins work?
The two hormones your body produces that are crucial for ovulation to take place are luteinising hormone (LH) and follicle-stimulating hormone (FSH).
Gonadotrophins are injectable forms of these hormones. They directly stimulate your ovaries to produce and ripen eggs.
The type of gonadotrophins that have been in use for the longest time contain both FSH and LH. These are called human menopausal gonadotrophins (hMG).
Some drugs, called follitropins, now contain only purified FSH. There is not much evidence to suggest that one type of gonadotrophin is better than another at stimulating the ovaries to produce mature eggs, although there may be differences in the cost or availability of some types.
You'll have gonadotrophins in conjunction with another hormone called human chorionic gonadotrophin (hCG). This hormone completes the final stage of egg maturation and can trigger ovulation, too.
How long will I need to be treated with gonadotrophins?
You can begin treatment any time when you're not ovulating. Your course of injections will continue daily for about 12 days each month, depending on how long it takes for your eggs to mature.
Your doctor might teach you how to give yourself the injections so you don't have to travel to the clinic every day. You may want your doctor to show your partner how to do the injections, if you don't want to do it yourself.
While you're having the injections, your doctor will monitor you to see when you're likely to ovulate. This means you'll have frequent ultrasound scans to check your ovaries. The scans will be carried out using a probe inserted into your vagina and shouldn't cause you any discomfort. You may need to have blood tests to check the levels of your hormones, too.
When the scan shows that your eggs are mature, you'll be given an injection of hCG to trigger ovulation. Ovulation usually occurs between 24 hours and 36 hours after the hCG injection.
You and your partner will need to time sex soon after your injection. If you're having IVF, the egg collection procedure will be scheduled for about 36 hours after your injection.
If you're being treated for an ovulation disorder, you're likely to have a maximum of three to six drug cycles. Success rates don't improve if you take the drugs for a longer time. If you try three times or more and don't get pregnant, your doctor may increase the dose or suggest another kind of treatment.
Do gonadotrophins have any side-effects?
It's possible that you may experience any of the following symptoms:
an allergic reaction to the drug
soreness or reaction at the injection site
You may find that giving yourself an injection directly into your muscle, probably your thigh, is difficult as it requires a long needle. The newer, purer gonadotrophins cause fewer side-effects and can be injected using smaller needles under your skin.
Taking these fertility drugs can be an emotionally intense process. As well as all the injections, you'll need to have frequent monitoring.
There's a risk with treatment involving gonadotrophins, and hCG in particular, of developing ovarian hyperstimulation syndrome (OHSS). This is when your ovaries rapidly swell to several times their usual size. Your ovaries may also leak fluid into your abdominal cavity.
Most cases of OHSS are mild. They result in:
mild abdominal pain
Severe OHSS is signalled by:
sudden, severe pain in your belly
thirst and other symptoms of dehydration
If a scan shows that your ovaries are developing too many eggs, you'll be advised not to have sex or exercise strenuously. This is to avoid the risk of injury to your swollen ovaries.
If you're trying to get pregnant without assisted conception, it can be disappointing to have to abandon a cycle of treatment. It's worth being cautious, though, as you also risk having a multiple pregnancy. This can lead to complications for you and your babies.
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